Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats.
Beaty SM., Nachbagauer R., Hirsh A., Vigant F., Duehr J., Azarm K., Stelfox AJ., Bowden TA., Duprex WP., Krammer F., Lee B.
To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV(JL5)), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the genomic background of MuV(JL5) Cross-reactivity and cross-neutralization between this chimeric rMuV(JL5)-F/HN(BMV) virus and rMuV(JL5) were demonstrated using hyperimmune mouse sera and a curated panel of human sera. All mouse and human sera that were able to neutralize rMuV(JL5) infection had cross-neutralizing activity against rMuV(JL5)-F/HN(BMV) Our data suggests that people who have neutralizing antibodies against MuV might be protected from infection by BMV.