Outcome of invasive pneumococcal disease: a UK based study. Oxford Pneumococcal Surveillance Group.
Shackley F., Knox K., Morris JB., Crook D., Griffiths D., Mayon-White R., George R., Willocks L., Moxon E.
METHODS: The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed. RESULTS: The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials. CONCLUSIONS: These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.