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We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microbial translocation, immune activation, or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

Original publication

DOI

10.1089/AID.2016.0198

Type

Journal article

Journal

AIDS Res Hum Retroviruses

Publication Date

02/2017

Volume

33

Pages

143 - 146

Keywords

HIV, antiretroviral therapy, immune activation, microbial translocation, viral reservoirs