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Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in allogeneic hematopoietic stem cell transplantation. This identified the TNF/TNR2 pathway as a swith and as a new target for immune checkpoint therapy to modulate the immune regulation in this clinical setting.

Original publication

DOI

10.1080/2162402X.2017.1373236

Type

Journal article

Journal

Oncoimmunology

Publication Date

2017

Volume

7

Keywords

Immune checkpoint, Immunomodulation, Immunotherapy, TNFR2, Treg