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Dengue infections are increasing at an alarming rate in many tropical and subtropical countries, where epidemics can put health care systems under extreme pressure. The more severe infections lead to dengue hemorrhagic fever (DHF), which can be life threatening. A variety of viral and host factors have been associated with the severity of dengue infections. Because secondary dengue infection is more commonly associated with DHF than primary infections, the acquired immune response to dengue, both B cells and T cells have been implicated. In this study, we set out to study T-cell responses across the entire dengue virus proteome and to see whether these were related to disease severity in a cohort of dengue-infected children from Thailand. Robust responses were observed in most infected individuals against most viral proteins. Responses to NS3 were the most frequent, and there was a very strong association between the magnitude of the response and disease severity. Furthermore, in DHF, cytokine-high CD107a-negative cells predominated.

Original publication

DOI

10.1073/pnas.1010867107

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

28/09/2010

Volume

107

Pages

16922 - 16927

Keywords

Dengue Virus, HLA-A Antigens, Humans, Proteome, Serine Endopeptidases, Severe Dengue, T-Lymphocytes