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An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re-engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses.

Original publication

DOI

10.1080/2162402x.2017.1318234

Type

Journal article

Journal

Oncoimmunology

Publication Date

03/08/2017

Volume

6

Pages

e1318234 - e1318234

Addresses

Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium.