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Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the disease. Through genomic epidemiology, we can appreciate bacterial population structure and its consequences for transmission dynamics, virulence, antimicrobial resistance, and development of new vaccines. Here, we review what we have learned through genomic epidemiological studies, following the rapid implementation of whole genome sequencing that can help to optimise preventative strategies for bacterial meningitis.

Original publication

DOI

10.12688/f1000research.13793.1

Type

Journal article

Journal

F1000Res

Publication Date

2018

Volume

7

Keywords

Bacterial meningitis, Neisseria meningitidis, genomic epidemiology, meningococcal disease, vaccine