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One of the most frequently mutated genes in human cancers, tumour suppressor p53 (TP53), can induce cell-cycle arrest and apoptosis. The apoptotic function of p53 is tightly linked to its tumour-suppression function and the efficacy of many cancer therapies depends on this. The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals. ASPPs might be new molecular targets for cancer therapy.

Original publication

DOI

10.1038/nrc1818

Type

Journal article

Journal

Nat Rev Cancer

Publication Date

03/2006

Volume

6

Pages

217 - 226

Keywords

Apoptosis, Cell Cycle, Humans, Neoplasms, Tumor Suppressor Protein p53