The team included researchers from NDM’s Translational Gastroenterology and Liver Unit, the Experimental Medicine Division as well as the Centre for Human Genetics, and were supported by the NIHR Oxford Biomedical Research Centre (BRC). They found that many of these changes in the gut persisted despite treatment with a gluten-free diet, suggesting there may be an immune 'scar' in the gut, which could explain why some patients experience ongoing symptoms.
Coeliac disease may be driven by immune structures in the gut
7 May 2025
Researchers in the Nuffield Department of Medicine have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease. These findings could provide a target for future therapies.
