Imaging

Oxford multiplex imaging users group

This group aims to connect researchers working with the numerous multiplex imaging technologies across the University, including Zellscanner (Peter Medawar Building), MIBIscope, CellDive (DPOC, Kennedy Institute of Rheumatology), Vectra Polaris (Old Road Campus Research Building), Codex (WIMM), Hyperion (WIMM), Nanostring GeoMx (NDS, JR). For more information about the group please join the Multiplex Imaging Users Group Teams site.

Oxford Biomedical Imaging Network

In 2007 the University established a joint MSD/MPLS Biomedical Imaging Network. This network links together the various departmental-based imaging programmes and attempts to promote a coordinated biomedical imaging strategy and collaborative environment. This Network has links to most imaging facilities across the University.

Micron Oxford Advanced Bioimaging Unit

Micron Oxford aims to develop and apply new and emerging advanced microscopy technologies to facilitate important discoveries in basic biomedical research. To achieve this, we coordinate and manage the interdepartmental and interdisciplinary cooperation required to lower the activation energy for biologists to become early adopters of advanced imaging methods.

Our advanced microscopy facilities are located across Oxford primarily in Biochemistry, Dunn School, WIMM and WTCHG. However, we include scientists in many other departments, including, Physics, Chemistry, Engineering, CNCB, DPAG, Kennedy and Diamond. Our facilities include all flavours of super resolution imaging modalities as well as single molecule methods and CLEM. We develop and adopt new technologies across all areas of Microscopy: Probe development, specimen preparation, instrument preparation and image analysis.

The Wolfson Imaging Centre

The Wolfson Imaging Centre at the WIMM contains a diverse range of wide-field and confocal microscopes suitable for imaging specimens ranging in complexity from single cells to small laboratory animals.

Dunn School Electron Microscopy Facility

The Dunn School Electron Microscopy (EM) Facility comprises state-of-the-art microscopes and offers the full gamut of EM techniques to facilitate a diverse range of biological and biomedical research. From scanning electron microscopy (SEM) and transmission electron microscopy (TEM), through to cutting-edge techniques such as correlative light and electron microscopy (CLEM), volume EM and elemental mapping using energy dispersive x-ray spectroscopy, we have the instrumentation and expertise to help you get the imaging results you need.

Cellular Imaging Core Facility (CICF) 

The Cellular Imaging Core Facility (CICF) is a major hub for microscopy in Oxford, providing imaging solutions from the organismal to the molecular level. The CICF is much more than a point of use facility. In addition to excellent quality tailored user training and ongoing support on all systems covering a wide range imaging modalities, we also offer advice and guidance throughout each stage of imaging projects. We strongly encourage users come to the core at the project conceptualisation stage, we then work with them through planning, sample preparation, imaging, data analysis, figure preparation and finally publication.

Oxford-ZEISS Centre of Excellence in Biomedical Imaging (Oxford-ZCoE)

The Kennedy Institute and IDRM have developed a unique and personal relationship with Carl Zeiss GMBH to form the Oxford-ZEISS Centre of Excellence in Biomedical Imaging (Oxford-ZCoE). This relationship allows users unrivalled access to state-of-the-art technologies and world-leading expertise. We have created an environment where our researchers and collaborators can truly tailor their microscopy experience and work directly with ZEISS R&D to realise their imaging needs.

Digital Omics Pathology Core (DPOC) Multiplex Imaging (Kennedy Institute of Rheumatology)

MIBIscope (IonPath) hyperplexed imaging technique enables high-dimensional tissue imaging for quantitative analysis of up to 54 metal ions at 300nm resolution and permits repeated sample scanning. The CellDive (GE) can stain up to 60 biomarkers on a single sample. When combined with single cell genomics, this approach offers a powerful approach to understanding the molecular and cellular processes driving tissue pathology in human disease and murine mechanistic models. This is augmented with 3D pathology imaging on the Open Top Light Sheet (OTLS) enabling imaging of needle biopsies. DPOC has established image analysis pipelines.

Kennedy Imaging Suite

In addition to the ZEISS instruments within the Oxford-ZCoE, the Kennedy hosts a number of other microscope platforms which are available for internal and external users. This suite of instruments facilitates imaging across the wide range of biologically relevant length scales resolvable using light microscopy. The BSU also hosts a Micro CT platform for animal X-ray tomography.

Nanosting GeoMx

This is available through the Translational Research Immunology Group (TRIG).