Sources of expertise in genome engineering
Genome Engineering Oxford
Genome Engineering Oxford is a joint venture between the Dunn School of Pathology, DPAG, Biochemistry and Pharmacology. We provide a CRISPR design and testing service for generating experimentally tested vectors and are actively involved in developing new CRISPR methods and applications.
WIMM Genome Engineering Facility
The Genome Engineering Facility at the WIMM is a central core service set up to establish genetically modified model systems and is available to all researchers.
TDI Cellular HTS - CRISPR Screening Facility
The CRISPR/Cas9 system is ideal for genome-wide knockout and gain of function screening experiments due to the ease of generating gRNAs and the efficiency and irreversibility of Cas9-mediated genetic modifications. Daniel Ebner's group at the TDI have pooled lentivirus CRISPR knock-out and activation libraries that target all the genes in human and mouse genome.