Contact information
Research groups
Alex Clarke
PhD FRCP
Associate Professor and Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre
- Associate Professor
- Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre
I qualified in Medicine from UCL in 2001, and trained in Rheumatology in London. Supported by a Wellcome Trust Clinical Research Training Fellowship, I completed a PhD on the role of autophagy in lupus in 2013, supervised by Tim Vyse at King’s College London.
After completing my medical specialist training, I moved to Oxford to join the group of Katja Simon at the Weatherall Institute of Molecular Medicine as a postdoctoral clinical fellow in 2014, again supported by the Wellcome Trust.
In 2018 I was awarded a Wellcome Trust Clinical Research Career Development Fellowship, establishing my own group here at the Kennedy Institute of Rheumatology.
Recent publications
The autoantigen TRIM21 assembles proinflammatory immune complexes following lytic cell death
Journal article
Jones Evana EL. et al, (2026), Science immunology
The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice.
Journal article
Johnstone JC. et al, (2026), PLoS Biol, 24
Checkpoint blockade amplifies pro-regenerative type 2 immunity in tissue repair.
Journal article
Romero Arocha S. and Clarke A., (2026), Nat Rev Immunol
Underlying data for 'The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice'
Dataset
Clarke ALEXANDER., (2026)
Successful treatment of refractory chilblain lupus erythematosus with bosentan.
Journal article
Gunawardana S. et al, (2025), Rheumatology (Oxford), 64, 6430 - 6431