Contact information
LOCATION:
Institute of Developmental and Regenerative Medicine, Old Road Campus, Oxford OX3 7TY
John Radcliffe Hospital, Level 6, Headley Way, Headington, Oxford, OX3 9DU
Colleges
Fadi Issa
DPhil FRCS(Plast)
Professor of Transplantation, Associate Head & Surgical Sciences Theme Lead
- Consultant Plastic, Reconstructive and Burns Surgeon
- Governing Body Fellow, Green Templeton College
- Academic Lead for Research Funding, Medical Sciences Division
I am Professor of Transplantation at the University of Oxford and a consultant surgeon. My work focuses on turning immunological insight into practical therapies that improve outcomes after organ and cell transplantation, and on broadening the use of immune targeted treatments in inflammatory and immune mediated disease. I integrate mechanistic immunology, biomarker and tissue based human studies, and early phase clinical trials, with a consistent emphasis on safety, durability, and real world implementation.
The Translational Research Immunology Group (TRIG) brings together graduate students, postdoctoral researchers, and clinical academics working across immunology, transplantation, tissue repair, and data driven translational science. We develop and test cellular and immunomodulatory therapies, and use deep immune profiling to understand mechanisms of response, resistance, and long term benefit. Our approach maintains a clear line of sight from discovery to patient impact.
Within Oxford, I serve as Associate Head of Department in the Nuffield Department of Surgical Sciences as Theme Lead for Surgical Sciences. I am also MSD Academic Lead for Research Funding and a Governing Body Fellow at Green Templeton College.
I am Editor in Chief of BMJ Immunology and an Executive Editor of Transplantation. I serve on the Steering Committee of FOCIS and previously chaired The Transplantation Society’s Transplantation Science Committee.
I am committed to building a rigorous and supportive training environment for early career researchers and clinicians, and welcome enquiries from prospective students, fellows, and collaborators.
Recent publications
TCR T cells targeting IgA- and IgG-expressing multiple myeloma.
Journal article
Douvlataniotis K. et al, (2026), Blood
Vortex-actuated pre-enrichment accelerates human regulatory T cell sorting and improves early fitness
Journal article
Ho QY. et al, (2026), Molecular Therapy Advances, 34, 201667 - 201667
People in Transplantation: Karin Hehenberger, MD, PhD.
Journal article
Issa F., (2026), Transplantation
CAR-mediated release of IL-10 increases the function of regulatory T cells: relevance for future clinical application.
Journal article
Saleem A. et al, (2026), Mol Ther
Professor Jeremy R. Chapman, AC: Editor-in-Chief, The Transplantation Journals.
Journal article
Issa F., (2026), Transplantation
Unraveling and leveraging the molecular structural determinants of chemokine receptor-ligand specificity.
Journal article
Ho QY. and Issa F., (2026), Am J Transplant, 26, 2 - 3
Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysis
Preprint
Cooper RA. et al, (2025)
HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model.
Journal article
McCallion O. et al, (2025), Nat Commun, 16
clinical investigation of a new gelling fibre dressing containing silver for the management of partial-thickness burns.
Journal article
Lewis CJ. et al, (2025), J Wound Care, 34, 797 - 804
Belantamab Mafodotin Triggers Immune Invigoration in Multiple Myeloma Via Inflammatory and Immunogenic Cell Death
Preprint
Watson ECR. et al, (2025)