Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis
OGG G. et al, (2019), Science Translational Medicine
Altered monocyte response to the dengue virus in those with varying severity of past dengue infection.
Kamaladasa A. et al, (2019), Antiviral Res
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis and a history of nonsteroidal immunosuppressant use: a post hoc analysis of the phase III CAFE trial
Bouaziz J-D. et al, (2019), BRITISH JOURNAL OF DERMATOLOGY, 181, 66 - 67
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.
Schwartz C. et al, (2019), Allergy
Correction: Synergistic activation of pro-inflammatory type-2 CD8 + T lymphocytes by lipid mediators in severe eosinophilic asthma.
Hilvering B. et al, (2019), Mucosal immunology, 12, 581 - 581