Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Developmental cell programs are co-opted in inflammatory skin disease.
Reynolds G. et al, (2021), Science, 371
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
PENG Y. et al, (2020), Nature Immunology
Innate Lymphocyte Mechanisms in Skin Diseases.
Chen Y-L. et al, (2020), 38, 171 - 202
Natural killer cells get under your skin.
Ogg G., (2020), Sci Transl Med, 12
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation
Chen Y-L. et al, (2019), Journal of Experimental Medicine