MRC Human Immunology Unit
MRC Weatherall Institute of Molecular Medicine
Professor of Dermatology
CD1a; Skin immunology; T cells; innate lymphoid cells
CD1a, T cells and the skin
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Specifically, we are working on skin T cells which respond to inflammatory lipids that are presented by CD1a. This turns out to be a very important part skin immune responses and we have been defining the underlying mechanisms. Our findings are also developing towards new approaches to modulate the CD1a pathway for patient benefit.
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Monnot GC. et al, (2022), Nat Immunol
CD1a promotes systemic manifestations of skin inflammation.
Hardman CS. et al, (2022), Nat Commun, 13
Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.
Fonseka CL. et al, (2022), Commun Biol, 5
HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses.
Buckley PR. et al, (2022), Immunology
An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.
Peng Y. et al, (2022), Nat Immunol, 23, 50 - 61