Jelena Bezbradica Mirkovic
KTRR Senior Research Fellow
I am a Senior Research Fellow of the Kennedy Trust for Rheumatology Research (KTRR) and an MRC New Investigator at the University of Oxford.
My research goal is to elucidate mechanisms that control the initiation of inflammatory responses. Innate immune cells, such as macrophages and dendritic cells are sentinels of tissue homeostasis. Our group investigates how these cells integrate signals from cytokines (which report on infection or tissue injury) with signals from microbial and tissue-damage sensors to direct the most appropriate effector response.
The NLRP3 inflammasome is one such critical sensor of cell and tissue homeostasis that becomes activated in response to pathogen- or tissue-derived danger signals. While beneficial during infections, excessive and uncontrolled NLRP3 activity contributes to the development of several inherited and acquired inflammatory diseases. Hence, we study how the NLRP3 pathway activity is ‘turned on and off’ in healthy individuals to be able to harness this knowledge for therapeutic interventions.
I earned my Ph.D. degree with Professor Sebastian Joyce at Vanderbilt University, USA. I continued my research training as a Damon Runyon Cancer Research Foundation and Howard Hughes Medical Institute postdoctoral fellow with Professor Ruslan Medzhitov at Yale University, USA, and with Professor Kate Schroder at The University of Queensland, Australia. I joined the Kennedy Institute in 2016.
Reinke S. et al, (2020), Vaccines (Basel), 8
Kumar A. et al, (2020), Proceedings of the National Academy of Sciences of the United States of America, 117, 17156 - 17165
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
WANN A. et al, (2020), Journal of Cell Science
NKT cells join the two step for inflammasome-independent IL-1b release
BEZBRADICA MIRKOVIC J. and Joyce S., (2020), Cell Reports
NUR77 HAS A CELL INTRINSIC ROLE IN NATURAL KILLER T CELL DEVELOPMENT AND FUNCTION
Kumar A. et al, (2019), JOURNAL OF IMMUNOLOGY, 202