Lars Fugger
Professor of Neuroimmunology
Research Summary
Multiple sclerosis (MS) is a common chronic inflammatory and degenerative disease of the central nervous system. Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease. Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. We are taking a multidisciplinary approach which is possible through a strong network of local and international collaborators. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group.
Recent publications
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Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade
Journal article
KAUR G. et al, (2022), Nature Communications
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Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Journal article
Kaufmann M. et al, (2022), Nat Neurosci
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The immunology of multiple sclerosis.
Journal article
Attfield KE. et al, (2022), Nat Rev Immunol
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MOG antibody-associated disease after vaccination with ChAdOx1 nCoV-19.
Journal article
Francis A. et al, (2022), Lancet Neurol, 21, 217 - 218
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Inflammation-related plasma and CSF biomarkers for multiple sclerosis.
Journal article
Huang J. et al, (2020), Proc Natl Acad Sci U S A