Professor of Neuroimmunology
Multiple sclerosis (MS) is a common chronic inflammatory and degenerative disease of the central nervous system. Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease. Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. We are taking a multidisciplinary approach which is possible through a strong network of local and international collaborators. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group.
B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.
du Pré MF. et al, (2019), The Journal of experimental medicine
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.
Ooi JD. et al, (2019), Nat Commun, 10
Systematic classification of shared components of genetic risk for common human diseases
Cortes A. et al, (2018)
HLA variation and disease.
Dendrou CA. et al, (2018), Nature reviews. Immunology, 18, 325 - 339
The Human Cell Atlas.
Regev A. et al, (2017), Elife, 6