Lars Fugger
Professor of Neuroimmunology
Research Summary
Multiple sclerosis (MS) is a common chronic inflammatory and degenerative disease of the central nervous system. Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease. Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. We are taking a multidisciplinary approach which is possible through a strong network of local and international collaborators. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group.
Recent publications
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A repair pathway lost in multiple sclerosis provides a new drug opportunity.
Jensen LT. et al, (2024), Nat Immunol, 25, 385 - 386
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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
Lippert AH. et al, (2024), Immunity
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Ancient DNA reveals evolutionary origins of autoimmune diseases.
Barrie W. et al, (2024), Nat Rev Immunol
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Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.
Barrie W. et al, (2024), Nature, 625, 321 - 328
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The selection landscape and genetic legacy of ancient Eurasians.
Irving-Pease EK. et al, (2024), Nature, 625, 312 - 320