Miles Carroll
Miles Carroll
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Our work centres around high consequence emerging viral infections. Currently, our focus is on Ebola, Lassa fever and SARS-CoV-2. We are interested in host-pathogen interactions, development of anti-virals and recently we have been looking at the IgG response following SARS-CoV-2 infection and/or vaccination in humans and animal models. To further support this work we are using a live virus neutralisation, multiplex immunoassays and novel ACE2 inhibition assay to inform on the ability of serum to neutralise SARS-CoV-2 variants of concern (VOC). We are also interested in the innate response to viral infection, particularly activation and/or evasion of the complement system
Recent publications
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Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals.
Mellors J. et al, (2025), Nat Commun, 16
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Detection of mpox and other orthopoxviruses using a lateral flow device as a point-of-care diagnostic.
Laidlaw SM. et al, (2025), Microbiol Spectr
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Using minor variant genomes and machine learning to study the genome biology of SARS-CoV-2 over time.
Dong X. et al, (2025), Nucleic Acids Res, 53
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Host-pathogen interactions of emerging zoonotic viruses: bats, humans and filoviruses.
Hood G. and Carroll M., (2024), Curr Opin Virol
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Therapeutics for Nipah virus disease: a systematic review to support prioritisation of drug candidates for clinical trials.
Chan XHS. et al, (2024), Lancet Microbe