Websites
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Williams Group | Targeting Disease Pathways in Rheumatoid Arthritis
Research Group, Kennedy Institute
Richard Williams
Professor
Richard Williams and his team focus on the development of novel therapeutic strategies for chronic inflammatory diseases, like rheumatoid arthritis. He previously focused on the role of TNFα, having successfully contributed to the successful development of anti-TNFα therapy. Subsequent work on combination therapy led to clinical trials of anti-TNFα plus methotrexate, which has set the gold standard for pharmacological management of rheumatoid arthritis.
He was a Senior Lecturer (2007-2011) and then Reader (2011-2012) at Imperial College London and led the Animal Models Group at the Kennedy Institute from 2003-2012.
He led a highly successful MRC DPFS funded project from 2009-2011 and initiated collaborative ventures with numerous pharmaceutical companies, including Merck, Pfizer, GSK, J&J, Bayer-Schering and Celgene.
He has been a Visiting Lecturer at UCL, QMUL and the London School of Hygiene and Tropical Medicine and as an Editor of Arthritis Research and Therapy for many years. He is now on the editorial board of Frontiers in Immunology and Cells and has acted as consultant to many pharmaceutical companies.
Recent publications
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Disease status in human and experimental arthritis, and response to TNF blockade, is associated with MHC class II invariant chain (CD74) isoform expression.
Journal article
CLANCHY F., (2022), Journal of Autoimmunity
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Editorial: Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications.
Journal article
Mándi Y. et al, (2022), Front Immunol, 13
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Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?
Journal article
Clanchy FIL. et al, (2022), Front Immunol, 13
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Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS).
Journal article
Ogbechi J. et al, (2022), Front Immunol, 13
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Standardization of Antigen-Emulsion Preparations for the Induction of Autoimmune Disease Models.
Journal article
Topping LM. et al, (2022), Front Immunol, 13
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Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity.
Journal article
Kogan NM. et al, (2021), Molecules, 26
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Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis
Journal article
WILLIAMS R. et al, (2021), Proceedings of the National Academy of Sciences of USA