Shoumo Bhattacharya
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
Shoumo Bhattacharya is Professor of Cardiovascular Medicine in the RDM Division of Cardiovascular Medicine at the University of Oxford and is based at the Wellcome Trust Centre for Human Genetics. He read medicine at the All India Institute of Medical Sciences in New Delhi, and trained in cardiology at Northwick Park and Hammersmith Hospitals in London, where he was also a MRC Training Fellow with James Scott working on RNA editing. He followed this with BHF and NIH Fellowships at the Dana-Farber Cancer Institute with David Livingston working on transcription factor protein interactions. He was a Wellcome Trust Senior Fellow at Oxford from 1998 to 2008, working on the transcriptional control of heart development, and their role in left-right patterning. He was elected Fellow of the Royal College of Physicians in 2003, awarded the Graham Bull Prize from the Royal College of Physicians in 2005, elected Fellow of the Academy of Medical Sciences in 2006. He was awarded a BHF Chair in 2009, and elected to a statutory Professorship at the University of Oxford in 2010. His primary role as BHF Chair has been the development of novel therapeutics and targets. The major focus of his lab is now the development of anti-inflammatory peptide therapeutics isolated from tick saliva that may have applications to myocarditis, post-myocardial infarction injury and myocardial fibrosis
Key publications
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
Vales S. et al, (2023), Nature Communications, 14
Recent publications
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Mutagenesis on a complex mouse genetic background by site-specific nucleases.
Davies B. et al, (2024), Transgenic Res
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
Vales S. et al, (2023), Nature Communications, 14
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Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia
Moreira L. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S85 - S86
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Phylogenetic Analysis Indicates That Evasin-Like Proteins of Ixodid Ticks Fall Into Three Distinct Classes
BHATTACHARYA S. and NUTTALL PA., (2021), Frontiers in Cellular and Infection Microbiology, 11
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Generation of an Abcg1 Knock Out Mouse on the Reversa Background
Douglas G. et al, (2016), ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36
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High Content Imaging Assay to Study Sprouting Angiogenesis Demonstrates A Key Role for Macrophage Endothelial Cell Interactions
Zen AAH. and Bhattacharya S., (2012), CIRCULATION, 126
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Aetiological Role Of Folate Deficiency In Congenital Cardiovascular Malformation: Evidence From "Mendelian Randomisation" And Meta-Analysis
Mamasoula C. et al, (2012), GENETIC EPIDEMIOLOGY, 36, 157 - 158
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A comparison of exogenous promoter activity at the ROSA26 locus using a PhiC31 integrase mediated cassette exchange approach in mouse ES cells
Biggs D. et al, (2011), TRANSGENIC RESEARCH, 20, 1174 - 1175
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Imaging Cardiac Developmental Malformations in the Mouse Embryo
Mohun T. et al, (2010), Heart Development and Regeneration: Volume I, 1, 779 - 791
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Dissecting the embryonic requirement of the Notch pathway gene, Hes1, in the context of DiGeorge syndrome
Papangeli I. et al, (2009), MECHANISMS OF DEVELOPMENT, 126, S130 - S130