Tal Arnon
PhD
Kennedy Trust of Rheumatology Research (KTRR) Senior Research Fellow
My PhD, at the Hebrew University of Jerusalem with Professor Ofer Mandelboim, focused on understanding how human natural killer cells recognize and eliminate virally infected cells.
As a postdoctoral fellow, in the University of California San Francisco with Professor Jason Cyster, I moved on to investigate mechanisms that regulate lymphocytes trafficking in vivo.
By developing advanced imaging methods using 2-photon microscopy our studies helped to understand the importance of specialized niches within the spleen in regulating immune cell migration and function.
In January 2014, I joined the Kennedy Institute as a Senior Research Fellow. In our current work, we continue to explore the unique features of splenic immune responses, focusing on the roles of specialized subsets of macrophages and innate immune cells in regulation of B cell behaviour.
Key publications
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Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress.
Journal article
Arnon TI. et al, (2013), Nature, 493, 684 - 688
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GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Journal article
Arnon TI. et al, (2011), Science, 333, 1898 - 1903
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Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.
Journal article
Muppidi JR. et al, (2011), J Exp Med, 208, 1941 - 1948
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Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.
Journal article
Arnon TI. et al, (2005), Nat Immunol, 6, 515 - 523
Recent publications
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to keep the scientific discussion going, we will renew our internal lab’s journal clubs with a paper presented once a week. As before, the formate will be informal, although you might need to make a few slides to communicate points you want to highlight. The choice of the paper is yours, but I would recommend to keep it not directly related to COVID19! Unless, of course, there is something you cannot resist.
Journal article
ARNON TI. et al, (2020), Immunity
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Visualisation of T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones
Journal article
ARNON TI. et al, (2020), Immunity
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Visualisation of T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones
Journal article
CHAUVEAU A. et al, (2020), Immunity
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Journal article
Reboldi A. et al, (2016), Science (New York, N.Y.), 352, aaf4822 - aaf4822
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Correction: harnessing soluble NK cell killer receptors for the generation of novel cancer immune therapy.
Journal article
Arnon TI. et al, (2015), PLoS One, 10