Tal Arnon
PhD
Kennedy Trust of Rheumatology Research (KTRR) Senior Research Fellow
My PhD, at the Hebrew University of Jerusalem with Professor Ofer Mandelboim, focused on understanding how human natural killer cells recognize and eliminate virally infected cells.
As a postdoctoral fellow, in the University of California San Francisco with Professor Jason Cyster, I moved on to investigate mechanisms that regulate lymphocytes trafficking in vivo.
By developing advanced imaging methods using 2-photon microscopy our studies helped to understand the importance of specialized niches within the spleen in regulating immune cell migration and function.
In January 2014, I joined the Kennedy Institute as a Senior Research Fellow. In our current work, we continue to explore the unique features of splenic immune responses, focusing on the roles of specialized subsets of macrophages and innate immune cells in regulation of B cell behaviour.
Recent publications
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Visualisation of T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones
Journal article
CHAUVEAU A. et al, (2020), Immunity
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Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal centre B cells in the spleen
Journal article
Pirgova G. et al, (2020), Proceedings of the National Academy of Sciences of USA
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to keep the scientific discussion going, we will renew our internal lab’s journal clubs with a paper presented once a week. As before, the formate will be informal, although you might need to make a few slides to communicate points you want to highlight. The choice of the paper is yours, but I would recommend to keep it not directly related to COVID19! Unless, of course, there is something you cannot resist.
Journal article
ARNON TI. et al, (2020), Immunity
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Visualisation of T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones
Journal article
ARNON TI. et al, (2020), Immunity
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Journal article
Reboldi A. et al, (2016), Science (New York, N.Y.), 352, aaf4822 - aaf4822