In this episode of To Immunity and Beyond, Professor Paul Klenerman talks with surgeon and immunologist Professor Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation.
Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.