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Statement on vaccine efforts relating to the Bundibugyo Ebolavirus outbreak in the Democratic Republic of the Congo

In response to the current Bundibugyo Ebolavirus outbreak in the Democratic Republic of the Congo, the Oxford Vaccine Group (OVG) is working urgently with Oxford’s own Clinical BioManufacturing Facility and the Serum Institute of India Pvt. Ltd. (SIIPL), to rapidly produce and scale doses of our ChAdOx-based monovalent Bundibugyo Ebolavirus candidate vaccine, ChAdOx1 BDBV.

Ebola virus

At the same time, we are working with our global partners to accelerate the generation of supportive preclinical data for the clinical development and testing of the ChAdOx1 BDBV vaccine in outbreak scenarios, all whilst continuing to follow established scientific, ethical, and regulatory standards.

For more than 30 years, researchers at OVG, in the Department of Paediatrics at the University of Oxford, have worked on the development and testing of vaccines against infectious diseases. In response to the 2013–2016 West African Ebola outbreak, OVG and the Jenner Institute led a number of clinical trials testing vaccines against Ebolavirus, including an expedited Phase II clinical trial of an adenovirus/MVA Ebola vaccine regimen, contributing to its approval by the European Medicines Agency in 2020.

The research team embedded in these trials have continued developing vaccines against multiple filoviruses, including Sudan Ebolavirus and Marburg virus. During outbreaks in Uganda, Equatorial Guinea and Tanzania between 2022 and 2025, vaccines designed and tested by Professor Teresa Lambe and her team based in OVG and the Pandemic Sciences Institute were selected by the World Health Organization for inclusion in ring vaccination trials, should they have been needed.

 

Read the full statement on the University of Oxford website.

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