Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment
Journal article
HANDEL A. et al, (2022), Science Advances
P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss.
Journal article
Stefanski HE. et al, (2022), PLoS One, 17
RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus.
Journal article
Jansen K. et al, (2021), Genome Res, 31, 2022 - 2034
FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency
Journal article
ROTA I. et al, (2021), Science Advances
Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα).
Journal article
Bainter W. et al, (2021), Sci Immunol, 6
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.
Journal article
Oftedal BE. et al, (2021), Commun Biol, 4
Indispensable epigenetic control of thymic epithelial cell development and function by Polycomb Repressive Complex 2
Journal article
HOLLANDER G., (2021), Nature Communications
Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells
Journal article
Asnaghi A. et al, (2021), Advanced Functional Materials
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
Journal article
Chen J. et al, (2021), Sci Adv, 7
Introduction: thymus development and function in health and disease.
Journal article
Holländer GA., (2021), Semin Immunopathol, 43, 1 - 3
Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations.
Journal article
Giardino G. et al, (2021), J Clin Immunol
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.
Journal article
Paolino M. et al, (2020), Nature
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
Journal article
Baran-Gale J. et al, (2020), eLife, 9
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Journal article
Oftedal B. et al, (2020), bioRxiv
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
Journal article
HOLLANDER G. et al, (2020), eLife
The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.
Journal article
Newman JA. et al, (2019), J Biol Chem
Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells"
Journal article
Handel AE. and Holländer GA., (2019), Journal of immunology (Baltimore, Md. : 1950), 203
Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells
Journal article
Dhalla F. et al, (2019), The EMBO Journal
Florescent timer protein as a molecular stop watch during embryonic thymic epithelial cell development
Conference paper
Cheuk S. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 355 - 356
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches.
Journal article
Bortolomai I. et al, (2019), Stem Cells Transl Med