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Publications

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment

HANDEL A. et al, (2022), Science Advances

P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss.

Stefanski HE. et al, (2022), PLoS One, 17

RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus.

Jansen K. et al, (2021), Genome Res, 31, 2022 - 2034

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

ROTA I. et al, (2021), Science Advances

Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα).

Bainter W. et al, (2021), Sci Immunol, 6

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.

Oftedal BE. et al, (2021), Commun Biol, 4

Indispensable epigenetic control of thymic epithelial cell development and function by Polycomb Repressive Complex 2

HOLLANDER G., (2021), Nature Communications

Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells

Asnaghi A. et al, (2021), Advanced Functional Materials

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.

Chen J. et al, (2021), Sci Adv, 7

Introduction: thymus development and function in health and disease.

Holländer GA., (2021), Semin Immunopathol, 43, 1 - 3

Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations.

Giardino G. et al, (2021), J Clin Immunol

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.

Paolino M. et al, (2020), Nature

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Baran-Gale J. et al, (2020), eLife, 9

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

Oftedal B. et al, (2020), bioRxiv

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

HOLLANDER G. et al, (2020), eLife

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

Newman JA. et al, (2019), J Biol Chem

Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells"

Handel AE. and Holländer GA., (2019), Journal of immunology (Baltimore, Md. : 1950), 203

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

Dhalla F. et al, (2019), The EMBO Journal

Florescent timer protein as a molecular stop watch during embryonic thymic epithelial cell development

Cheuk S. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 355 - 356

Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches.

Bortolomai I. et al, (2019), Stem Cells Transl Med

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