Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways.
Feng S. et al, (2024), Nat Commun, 15
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.
Su P. et al, (2024), Nat Genet
Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer.
Hosseini A. et al, (2024), Cell Rep, 43