Research groups
Websites
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MRC Human Immunology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Christian Eggeling
PhD
Professor of Molecular Immunology
Nano-Immunology
We apply and optimize advanced optical microscopy techniques such as super-resolution STED microscopy for deciphering molecular dynamics in so far unprecedented ways. Our main focus is molecular plasma membrane organization, especially following immune responses. For further information see: www.nano-immunology.org.
Prof Eggeling holds a PhD in Physics from the University of Göttingen, where he optimized single-molecule detection. From 2000 to 2003 he was a research scientist at Evotec, Hamburg, developing advanced fluorescence microscopy techniques for high-throughput drug screening. In 2003, Christian joined the MPI of Biophysical Chemistry, Göttingen as a senior scientist in the department of Professor Stefan Hell (2014 Nobel Laureate in Chemistry). Here, he was focused on the field of optical super-resolution microscopy, specifically the biological applicability of stimulated emission depletion (STED) microscopy.
Since 2012, Christian has been a principal investigator in the MRC Human Immunology Unit and the scientific director of the Wolfson Imaging Centre at the MRC Weatherall Institute of Molecular Medicine, University of Oxford. From 2014, as a Professor of Molecular Immunology, Christian's research has been focused on advanced microscopy for the investigation of immune cells and cellular plasma membrane organization.
Recent publications
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Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells
Journal article
Bedard M. et al, (2019), Proceedings of the National Academy of Sciences
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HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly
Journal article
Favard C. et al, (2019), Science Advances, 5, eaaw8651 - eaaw8651
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High photon count rate super-resolution fluorescence fluctuation spectroscopy
Journal article
Schneider F. et al, (2019)
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Adaptive optics allows STED-FCS measurements in the cytoplasm of living cells
Journal article
Barbotin A. et al, (2019), Optics Express, 27, 23378 - 23395
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Elucidating the nanoscale architecture of the plasma membrane with super-resolution spectroscopy
Conference paper
Sezgin E. and Eggeling C., (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S57 - S57