Associate Professor David Eyre
Research groups
David Eyre
Associate Professor
- Robertson Fellow
- Infectious Diseases Clinician
My research interests include the use of whole-genome sequencing as a tool for understanding the epidemiology and transmission of bacterial and fungal pathogens. My previous work has described the transmission of the major healthcare-associated pathogen Clostridium difficile and has also included large-scale sequencing projects tracking the spread of gonorrhoea and the emerging multi-drug resistant fungus Candida auris. I am currently working on developing mathematical models for pathogen transmission that allow risk factors for transmission to be identified, as a means to suggest potential interventions to prevent infections spreading.
I am also interested in using sequencing technologies as a novel tool for culture-independent microbiology diagnostics. These technologies offer the prospect of same-day diagnosis of infection, rather than having to wait several days for bacteria to grow in the lab. I have developed methods using sequencing data to detect the presence of infection, e.g. from orthopedic devices removed from patients, as well as predict antibiotic resistance, e.g. in Enterobacteriaceae and Neisseria gonorrhoeae.
Additionally I work on using routinely collected healthcare data to investigate the epidemiology of infectious diseases and to investigate individual patient responses to infection and treatment.
I work closely with the Modernising Medical Microbiology consortium on several of these projects.
Recent publications
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Clinical Metagenomic Sequencing for Species Identification and Antimicrobial Resistance Prediction in Orthopedic Device Infection.
Journal article
Street TL. et al, (2022), J Clin Microbiol
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Divergent trajectories of antiviral memory after SARS-CoV-2 infection.
Journal article
Tomic A. et al, (2022), Nat Commun, 13
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K-mer based prediction of Clostridioides difficile relatedness and ribotypes
Journal article
MOORE M. et al, (2022), Microbial Genomics
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Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines.
Journal article
Wei J. et al, (2022), Nat Med
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Infection prevention and control insights from a decade of pathogen whole-genome sequencing.
Journal article
Eyre DW., (2022), J Hosp Infect