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MHC class II molecules bind peptides derived from extracellular proteins that have been ingested by antigen-presenting cells and display them to the immune system. Peptide loading occurs within the antigen-presenting cell and is facilitated by HLA-DM. HLA-DM stabilizes the open conformation of the MHCII binding groove when no peptide is bound. While a structure of the MHCII/HLA-DM complex exists, the mechanism of stabilization is still largely unknown. Here, we applied customized Natural Move Monte Carlo to investigate this interaction. We found a possible long-range mechanism that implicates the configuration of the membrane-proximal globular domains in stabilizing the open state of the empty MHCII binding groove.

Original publication

DOI

10.1021/acs.jcim.9b00104

Type

Journal article

Journal

Journal of chemical information and modeling

Publication Date

28/05/2019

Addresses

Biotech Research and Innovation Centre , University of Copenhagen , Copenhagen 2200 , Denmark.