Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The principal immune function of the afferent lymphatics is to bear antigen and leukocytes from peripheral tissues to the draining lymph nodes. Recent research has shown that passage of leukocytes into the afferent lymphatic capillaries is far from an indolent process; rather it is carefully orchestrated by an array of adhesion molecules, as well as by chemokines and their receptors. Here we review the current knowledge of leukocyte trans-lymphatic endothelial migration and its role in the development of an immune response.

Original publication




Journal article


Ann N Y Acad Sci

Publication Date





119 - 133


Animals, Cell Movement, Chemokine CCL21, Dendritic Cells, Endothelium, Lymphatic, Humans, Intercellular Adhesion Molecule-1, Leukocytes, Models, Biological, Receptors, CCR7, Vascular Cell Adhesion Molecule-1