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Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.

Original publication

DOI

10.1038/sj.gene.6364045

Type

Journal article

Journal

Genes Immun

Publication Date

05/2004

Volume

5

Pages

151 - 157

Keywords

Arthritis, Rheumatoid, Genetic Predisposition to Disease, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Major Histocompatibility Complex