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While twin studies have previously demonstrated high heritability of susceptibility to ankylosing spondylitis (AS), it is only recently that the involvement of genetic factors in determining the severity of the disease has been demonstrated. The genes involved in determining the rate of ankylosis in AS are likely to be different from those involved in the underlying immunologic events, and represent important potential targets for treatment of AS. This article will describe the progress that has been made in the genetic epidemiology of AS, and in identifying the genes involved.

Type

Journal article

Journal

Curr Opin Rheumatol

Publication Date

07/2002

Volume

14

Pages

354 - 360

Keywords

Chromosome Mapping, Diseases in Twins, Gene Expression, Genetic Predisposition to Disease, Humans, Molecular Epidemiology, Spondylitis, Ankylosing