Site Map
Accessibility
Cookies
Contact us
Log in
Home
About us
News
Events
Research
Resources
Impact
HIDI
COVID-19
OIG
Search
Publications
Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease
Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease
PLATT F., Kaya E., Smith C., Smith D.
Type
Journal article
Journal
Journal of Clinical Medicine
Publisher
MDPI
Publication Date
07/04/2020
About us
The Immunology Network
Strategic Objectives
Steering Committee
History
Contact us
Our Team
Berlin-Oxford Initiative
News
Events
Research
Basic Immunology
Computational Immunology
Immunometabolism
Immuno-Oncology
Infection
Inflammation
Neuroimmunology
Structural Immunology
Translational Immunology
Vaccines
Resources
Funding
Facilities
Imaging
Bioinformatics
Genome Engineering
Cytometry
Immunology Teaching Network
Researchers' Toolkit
Research Nurses
Networks, Consortia, Initiatives, Groups
Communication
Study
ORNIID
ORNIID
Research
About Us
Collaboration
Education and Career development
Impact
Putting ticks on the map
Influencing HIV/AIDS policy in India through mathematical modelling
Improving lives for families affected by HIV and AIDS
Defeating dengue with GM mosquitoes
Two cancer therapies are better than one
Transforming the diagnosis of Tuberculosis
Combining cultures
Human Immune Discovery Initiative (HIDI)
HIDI Overview
How to use HIDI
HIDI Internal Fund
Contact us
HIDI Day, 1 Oct, 2018
COVID-19
COVID-19 Immunology Research
COVID-19 Literature Reviews
Proteomics identifies a type I IFN, prothrombotic hyperinflammatory circulating COVID-19 neutrophil signature distinct from non-COVID-19 ARDS
SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating 2 monocytes and alterations in both dendritic cell and monocyte subsets
CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
Functional Landscape of SARS-CoV-2 Cellular Restriction
Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients
Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry
Identification and characterization of an immunodominant SARS-CoV-2-specifc CD8 T cell response
Gastrointestinal involvement attenuates COVID-19 severity and mortality
Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome
Coronavirus disease 2019 induced inflammatory response are associated with changes in lipid profiles
Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike
Seroprevalence of SARS-CoV-2 in an Asymptomatic US Population
Antibody binding to SARS-CoV-2 S glycoprotein correlates with, but does not predict neutralization
Bacterial pulmonary superinfections are associated with unfavourable outcomes in critically ill COVID-19 patients
The Monocyte Chemotactic Protein 1 as a Potential Indicator for SARS-CoV-2 Infected Mild COVID-19 Patients
Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
T cell anergy in COVID-19 reflects virus persistence and poor outcomes
Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report
A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody
A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection
Dynamic changes in serum IL-6, IL-8, and IL-10 are associated with the outcome of patients with severe COVID-19 in ICU
KIM-1/TIM-1 is a receptor for SARS-CoV-2 in Lung and Kidney
A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters
Comparative evaluation of six immunoassays for the detection of antibodies against SARS-CoV-2
Asymptomatic reinfection in two healthcare workers from India with genetically distinct SARS-CoV-2
Laboratories biomarkers associated with COVID-19 severity and management
The immunodominant and neutralization linear epitopes for SARS-CoV-2
Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy
Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Baricitinib restrains the immune dysregulation in severe COVID-19 patients
Presence of Genetic Variants Among Young Men With Severe COVID-19
COVID-19 severity associates with pulmonary redistribution of CD1c+ DC and inflammatory transitional and nonclassical monocytes
Rapid evaluation of neutralizing antibodies in COVID-19 patients
Cross-reactive antibody responses against SARS-CoV-2 and seasonal common cold coronaviruses
Prime-boost protein subunit vaccines against SARS2 CoV-2 are highly immunogenic in mice and macaques
Systematic examination of T cell responses to SARS-CoV-2 versus influenza virus reveals distinct inflammatory profile
A comprehensive analysis of recovered COVID-19 patients and dynamic trend in antibodies over 3 months using ELISA and CLIA methods
Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
Rare SARS-CoV-2 antibody development in cancer patients
Engineered interferon alpha effectively improves clinical outcomes of COVID-19 patients
SARS-CoV-2 RNA viremia is associated with a sepsis-like host response and critical illness in COVID-19
A Preliminary Study on Blood Lipid Profile in Patients with COVID-19
Changes in lipid metabolism in patients with severe COVID-19
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
SARS-CoV-2 spike protein interacts with multiple innate immune receptors
SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2
Pre-COVID-19 humoral immunity to common coronaviruses does not confer cross-protection against SARS-CoV-2
Suboptimal SARS-CoV-2-specific CD8+ T-cell response associated with the prominent HLA-A*02:01 phenotype
In plain sight: the role of alpha-1-antitrypsin in COVID-19 pathogenesis and therapeutics
SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
Convalescent plasma for patients with severe COVID-19: a matched cohort study
Decline of SARS-CoV-2 specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge
The analysis of the long-term impact of SARS-CoV-2 on the cellular immune system in individuals recovering from COVID-19 reveals a profound NKT cell impairment
The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing optimal formation of VLPs in presence of Nucleoprotein
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19
Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
Disease severity dictates SARS-CoV-2 specific neutralizing antibodyresponses in COVID-19
Evidence favouring the efficacy of convalescent plasma for COVID-19 therapy
A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses
A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection
Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate
A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine
Loss expansion of SARS-CoV-2 specific immunity is a key risk factor in fatal patients with COVID-19
Host metabolic reprogramming in response to SARS-Cov-2 infection
SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum
Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) Protein Inhibits Type I and III Interferon Production by Targeting RIG-I/MDA-5 Signaling
Infection of human lymphomononuclear cells by SARS-CoV-2
COVID-19 and Rheumatoid Arthritis share myeloid pathogenic and resolving pathways
Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model
COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2
The loss of Bcl-6 expressing T follicular helper cells and the absence of germinal centers in COVID-19
Single cell RNA sequencing of blood antigen-presenting cells in severe Covid-19 reveals multi-process defects in antiviral immunity
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization
A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip
Circulating cytokines and lymphocyte subsets in patients who have recovered from COVID-19
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
Tissue-specific and interferon-inducible expression of non-functional ACE2 through endogenous retrovirus co-option
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kB
Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates
Concurrent human antibody and TH1 type T-cell responses elicited by a COVID-19 RNA vaccine
Interplay of Monocytes and T Lymphocytes in COVID-19 Severity
SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
Dynamics and significance of the antibody response to SARS-CoV-2 infection
Broad phenotypic alterations and potential dysfunctions of lymphocytes in COVID-19 recovered individuals
Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection
SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months
Neutralizing Antibody Responses in COVID-19 Convalescent Sera
COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Beta-Coronaviruses use lysosomal organelles for cellular egress
Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19
Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19
Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8+ T cells
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)
SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation
Natural killer cell activation related to clinical outcome of COVID-19
Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs
Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19
A shift towards an immature myeloid profile in peripheral blood of critically ill COVID-19 patients
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
Baricitinib restrains the immune dysregulation in COVID-19 patients
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
SARS-CoV-2 reactive T cells in uninfected individuals are likely expanded by beta-coronaviruses
Structure of the full SARS-CoV-2 RNA genome in infected cells
Seroconversion of a city: Longitudinal monitoring of SARS-CoV seroprevalence in New York City
SARS-CoV-2 serological testing using electrochemiluminescence reveals a rapid onset of seroconversion in severe COVID-19 patients
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes
In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age
Proteomic blood profiling in mild, severe and critical COVID-19 patients
A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection
Elevated Nucleoprotein-Induced Interferon-γ Release in COVID-19 Patients Detected in a SARS-CoV-2 Enzyme-Linked Immunosorbent Spot Assay
Neuroinvasive potential of SARS-CoV-2 revealed in a human brain organoid model
Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune Response without Seroconversion
Tocilizumab and steroid treatment in patients with COVID-19 pneumonia
In silico immune infiltration profiling reveals the role of naïve B cells in lung tissues of COVID-19 patients
Spectrum of innate and adaptive immune response to SARS CoV 2 infection across asymptomatic, mild and severe cases; a longitudinal cohort study
Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
Two distinct immunopathological profiles in lungs of lethal COVID-19
SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids
Longitudinal immunological analyses reveal inflammatory misfiring in severe COVID-19 patients
Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients
Antiviral Drug Screen of Kinase inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication
Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19
Early temporal dynamics of cellular responses to SARS-CoV-2
Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
NK cell receptor NKG2C deletion and HLA-E variants are risk factors for severe COVID-19
Living repository of millions of T and B cell receptor sequences from patients with COVID-19
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
SARS-CoV-2 T-cell epitopes define heterologous and COVID-19-induced T-cell recognition
A longitudinal study of immune cells in severe COVID-19 patients
Microscopy-based assay for semi-quantitative detection of SARS-CoV2 specific antibodies in human sera
Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
A single dose of an adenovirus-vectored vaccine provides complete protection of the upper and lower respiratory tracts against SARS-CoV-2 challenge
SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients
Drug repurposing screens reveal FDA approved drugs active against SARS-CoV-2
Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells
Age-dependent progression of SARS-CoV-2 infection in Syrian hamsters
Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
Highly sensitive and specific multiplex antibody assays to quantify immunoglobulins M, A and G against SARS-CoV-2 antigens
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals
Engineering mesenchymal stem cells with neutralizing and anti- inflammation dual-capability against SARS-CoV-2 infection
SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models
IgA dominates the early neutralizing antibody response to SARS-CoV-2
Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate
SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology
SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19
Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids
Immune Response Profile of SARS-CoV-2 Associated ARDS Patients During Extracorporeal Membrane Oxygenation
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
A consensus Covid-19 immune signature combines immune-protection with discrete sepsis-like traits associated with poor prognosis
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness
Profound CD8 T cell responses towards the SARS-CoV-2 ORF1ab in COVID-19 patients
Acute SARS-CoV-2 infection impairs dendritic cell and T cell responses
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
Therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022
SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus
Gut mycobiota alterations in patients with COVID-19 and H1N1 and associations with immune and gastrointestinal symptoms
Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease
An open resource for T cell phenotype changes in COVID-19 identifies IL-10-producing regulatory T cells as characteristic of severe cases
Activation of Peroxiredoxin 1 by Fluvastatin Effectively Protects from Inflammation and SARS-CoV-2
Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects
Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge
Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity
Expansion of SARS-CoV-2-specific Antibody-secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients
Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors
Suppressive myeloid cells are a hallmark of severe COVID-19
SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
Metatranscriptomic Characterization of COVID-19 Identified A Host Transcriptional Classifier Associated With Immune Signaling
Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals
Chemokine Receptor Inhibitor vMIP-II Promoting Lymphocytes in COVID-19 Patients and Its Related Mechanism In Vitro
Development and validation of IMMUNO-COVTM: a high-throughput clinical assay for detecting antibodies that neutralise SARS-CoV-2
Single-Cell Analysis Reveals Macrophage-Driven T Cell Dysfunction in Severe COVID-19 Patients
Sars-Cov-2 Spike 1 protein control Natural killer cells activation via HLA-E/NKG2A pathway
Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis dependent axis
Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19
Generation of human bronchial organoids for SARS-CoV-2 research
A systems approach to inflammation identifies therapeutic targets in SARSCoV-2 infection
Impaired T cell functions along with elevated activated Tregs at the early stage of asymptomatic SARS-CoV-2 infection
Identification of immune complement function as a determinant of adverse SARS-CoV-2 infection outcome
Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2
SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I
Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates
Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 via STAT3 signaling in rheumatoid synovium
Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2
Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir
Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients
Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease
Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells
SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencing
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis
The SARS-CoV-2 spike protein primes inflammasome-mediated interleukin-1- beta secretion in COVID-19 patient-derived macrophages
Tropism, replication competence, and innate responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures
Symptomatic SARS-CoV-2 infections display specific IgG Fc structures
A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators
Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals
The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells
SARS-CoV-2 infection protects against rechallenge in rhesus macaques
Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses
Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
DNA vaccine protection against SARS-CoV-2 in rhesus macaques
Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures
SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects
Convalescent plasma treatment of severe COVID-19: A matched control study
Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model
Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
In Search of Preventative Strategies: Novel Anti- Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues
Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19
The anticoagulant nafamostat potently inhibits SARS-CoV-2 infection in vitro： an existing drug with multiple possible therapeutic effects
Robust ACE2 protein expression localises to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Serum protein profiling reveals a landscape of inflammation and immune signalling in early-stage COVID-19 infection
Novel ACE2-Independent Carbohydrate-Binding of SARS-CoV-2 Spike Protein to Host Lectins and Lung Microbiota
Longitudinal Profiling of Cytokines and Chemokines in COVID-19 Reveals Inhibitory Mediators IL-1Ra and IL-10 Are Associated with Disease Severity While Elevated RANTES Is an Early Predictor of Mild Disease
Infection of bat and human intestinal organoids by SARS-CoV-2
Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19
Reappearance of Effector T Cells Predicts Successful Recovery from COVID-19
A Translatable Subunit Nanovaccine for COVID-19
Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans
Distinct conformational states of SARS-CoV-2 spike protein
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Potent neutralization of SARS-CoV-2 in vitro and in an animal model by a human monoclonal antibody
ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques
A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities
Rapid response flow cytometric assay for the detection of antibody 2 responses to SARS-CoV-2
A rapid, point of care red blood cell agglutination assay for detecting antibodies against SARS-CoV-2
Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection
SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant
Suramin inhibits SARS-CoV-2 infection in cell culture by interfering with early steps of the replication cycle
Evidence of a significant secretory-IgA-dominant SARS-CoV-2 immune response in human milk following recovery from COVID-19
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
SARS-CoV-2 Infection of the Placenta
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site
Mass spectrometry analysis of newly emerging coronavirus HCoV-19 spike S protein and human ACE2 reveals camouflaging glycans and unique post-translational modifications
A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells
Replication of SARS-CoV-2 in human respiratory epithelium
Treatment of Severe COVID-19 with human Umbilical Cord Mesenchymal Stem Cells
Characteristics of lymphocyte subsets and their predicting values for the severity of COVID-19 patients
B cell clonal expansion and convergent antibody responses to SARS-CoV-2
Identification of immune checkpoints in COVID-19
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
Comprehensive characterization of N- and O- glycosylation of SARS- CoV-2 human receptor angiotensin converting enzyme 2
Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients
Shared Antigen-specific CD8 T cell Responses Against the SARS-COV-2 Spike Protein in HLA-A*02:01 COVID-19 Participants
Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform
Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identify molecular targets for therapeutic intervention
Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19
Early viral clearance and antibody kinetics of COVID-19 among asymptomatic carriers
A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures
Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19
Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease: A retrospective study
Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non- human primates
A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
Host-viral infection maps reveal signatures of severe COVID-19 patients
An age dependent pharyngeal microbiota signature associated with SARS-CoV-2 infection
Rapid adaption of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy
Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes During Covid-19 Infection
Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support
SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems
Increased circulating microparticles and inflammatory factors aggravate coronavirus disease 2019 (COVID19)
Lectin-like intestinal defensin inhibits 2019-nCoV spike binding to ACE2
Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
Virological assessment of hospitalised patients with COVID-2019
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice
Distinct Inductions of and Responses to Type I and Type III Interferons Promote Infections in Two SARS-CoV-2 Isolate
A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques
Successful manufacturing of clinical grade SARS-CoV-2 specific T cells for adoptive T cell therapy
Critically ill SARS-CoV-2 patients display lupus-like hallmarks of extrafollicular B cell activation
Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies
Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells
Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model
Heightened innate immune responses in the respiratory tract of COVID-19 patients
A possible role of immunopathogenesis in COVID-19 progression
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin
All-in-One Dual CRISPR-Cas12a (AIOD-CRISPR) Assay: A Case for Rapid, Ultrasensitive and Visual Detection of Novel Coronavirus SARS-CoV-2 and HIV virus
Thymosin alpha-1 Protected T Cells from Excessive Activation in Severe COVID-19
Detection of SARS-COV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals
Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines
A single-cell atlas of the peripheral immune response to severe Covid-19
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection, Replication and Spread in Primary Human Intestinal Epithelial Cells
SARS-CoV-2 Productively Infects Human Gut Enterocytes
TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes
Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Gut microbiota may underlie the predisposition of healthy individuals to COVID-19
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
Rapid development of an inactivated vaccine for SARS-CoV-2
Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases
COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by a quantitative and sensitive immunoassay
Treating Influenza and SARS-CoV-2 via mRNA-encoded Cas13a
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients
A SARS-CoV-2 surrogate virus neutralization test (sVNT) based on antibody-mediated blockade of ACE2-spike (RBD) protein-protein interaction
Marked T cell activation, senescence, exhaustion and skewing towards Th17 in patients with Covid-19 pneumonia
Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs
Efficacy and safety of lopinavir/ritonavir or arbidol in adult patients with mild/moderate COVID-19: an exploratory randomized controlled trial
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Survival Factors and Metabolic Pathogenesis in Elderly Patients (≥65) with COVID-19 : A multi-center study of 223 Cases
Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19
STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters
The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia
Increased expression of CD8 marker on T-cells in COVID-19 patients
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series
Acute eosinophilic pneumonia associated with elevated NKT cell response in COVID-19 patients
Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19
Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients
CRISPR–Cas12-based detection of SARS-CoV-2
Humanized Single Domain Antibodies Neutralize SARS-CoV-2 by Targeting 2 Spike Receptor Binding Domain
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study
Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Multiscale 3-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome
Identification of 22 N-glycosites on Spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: implications on vaccination and antibody therapeutics
The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-CoV-2) replication and attenuates inflammation in human cells
Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2- mediated complement over-activation
Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza
Imbalanced host response to SARS-CoV-2 drives development of COVID-19
A serological assay to detect SARS-CoV-2 seroconversion in humans
Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases
Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia
Analytical Validation of a COVID-19 qRT-PCR Detection Assay Using a 384-well Format and Three Extraction Methods
Potent human neutralizing antibodies elicited by SARS-CoV-2 infection
SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
A dynamic immune response shapes COVID-19 progression
Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene 3 expression in the airway epithelium
Effectiveness of convalescent plasma therapy in severe COVID-19 patients
Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis
Complex immune dysregulation in COVID-19 patients with severe respiratory failure
The phenotypic changes of γδ T cells in COVID-19 patients
Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS- CoV-2 by Remdesivir
Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production
Reinfection could not occur in SARS-CoV-2 infected rhesus macaques
Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro
Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study
SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice
Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro
An Infectious cDNA Clone of SARS-CoV-2
Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection
Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2
Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)
Rapid development of a synthetic DNA vaccine for COVID-19
An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors' CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design
Analysis of adaptive immune cell populations and phenotypes in the patients infected by SARS-CoV-2
The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice
Structural basis of receptor recognition by SARS-CoV-2
Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients
Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including the newly emerged coronavirus SARS-CoV-2
Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells
The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
Structure, function and antigenicity of the SARS-CoV-2 Spike Protein
A human monoclonal antibody blocking SARS-CoV-2 infection
Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV
SARS-CoV-2 may persist in digestive tract longer than respiratory tract
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
ACE2 expression by colonic epithelial cells is associate with viral infection, immunity and energy metabolism
Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus
Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19
Dysregulation of immune response in patients with COVID-19 in Wuhan, China
The potential role of IL-6 in monitoring severe case of coronavirus disease 2019
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
SARS-CoV-2 is sensitive to type 1 interferon pretreatment
SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing
Alveolar macrophage activation and cytokine storm in the pathogenesis of severe COVID-19
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
Publications from Oxford Immunology Network Researchers
OIG
Talks
Contact or join us
OIG Committee
