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<jats:title>Abstract</jats:title> <jats:p>A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at risk individuals.</jats:p>

Original publication




Journal article


The Journal of Infectious Diseases


Oxford University Press (OUP)

Publication Date