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We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

Original publication

DOI

10.1038/ng2058

Type

Journal article

Journal

Nat Genet

Publication Date

07/2007

Volume

39

Pages

827 - 829

Keywords

Animals, Celiac Disease, Chromosomes, Human, Pair 4, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Humans, Interleukin-2, Interleukins, Linkage Disequilibrium, Mice, Polymorphism, Single Nucleotide, Risk Factors