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BACKGROUND AND AIM: Although the gut microbiome of patients with ulcerative colitis (UC) has been characterized, no study has characterized the gut microbiome in acute severe colitis (ASC). We compared the gut microbiome of patients with UC, ASC, and healthy controls (HCs). METHODS: Patients with mild to moderate UC (n = 24), ASC (n = 19 with 21 episodes) and HCs (n = 50) were recruited prospectively. A 16SrDNA amplicon approach was used to explore gut microbial diversity and taxonomic repertoires. UC was diagnosed using European Crohn's and Colitis Organization guidelines, and ASC was diagnosed using Truelove and Witts' criteria. RESULTS: The normalized alpha diversity was significantly lower in ASC than mild-moderately active UC (P 

Original publication




Journal article


J Gastroenterol Hepatol

Publication Date





731 - 739


Abundance, Acute severe colitis, Gut microbiome, Ulcerative colitis, Acute Disease, Adolescent, Adult, Colitis, Colitis, Ulcerative, Female, Gastrointestinal Microbiome, Humans, Male, Microbiological Techniques, Middle Aged, Nucleic Acid Amplification Techniques, RNA, Ribosomal, 16S, Severity of Illness Index