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SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

Original publication

DOI

10.2807/1560-7917.ES.2020.25.41.2001721

Type

Journal article

Journal

Euro Surveill

Publication Date

10/2020

Volume

25

Keywords

COVID-19, ELISA, IgG, antenatal, antibody, epidemiology, neutralisation, pregnancy, prevalence, serology