Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID‐19: Analysis of the ISARIC CCP‐UK cohort
Yates T., Zaccardi F., Islam N., Razieh C., Gillies CL., Lawson CA., Chudasama Y., Rowlands A., Davies MJ., Docherty AB., Openshaw PJ., Baillie JK., Semple MG., ISARIC4C investigators None., Khunti K.
Objective To investigate the association of obesity with in‐hospital COVID‐19 outcomes in different ethnic groups. Methods Patients admitted to hospital with COVID‐19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP‐UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from 6th February to 12th October 2020. Ethnicity was classified as: white, South Asian, black and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation and in‐hospital mortality, adjusted for age, sex and chronic diseases. Results 54,254 (age = 76 years; 45.0% women) white, 3,728 (57 years; 41.1%) South Asian, 2,523 (58 years; 44.9%) black and 5,427 (61 years; 40.8%) other ethnicities were included. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the OR for admission to critical care, mechanical ventilation and mortality in black ethnicities with obesity were 3.91 (3.13, 4.88), 5.03 (3.94, 6.63), 1.93 (1.49, 2.51) respectively, compared to white ethnicities without obesity. Conclusions Obesity was associated with an elevated risk of in‐hospital COVID‐19 outcomes in all ethnic groups, with associations strongest in black ethnicities.