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A branched DNA (bDNA)-based quantitation of plasma human immunodeficiency virus type I (HIV-I) RNA was used to monitor the virologic status of 102 patients (29-906 CD4 cells/mm3) enrolled in clinical trials of antiretroviral and immune-based therapies. Virion-associated RNA was measurable in plasma of74% of patients tested (10, 000-10, 000, 000 RNA equivalents/mL). Virus levels measured by the bDNA assay exceeded titers obtained by quantitative plasma culture and were inversely correlated (r = -.378; P

Original publication




Journal article


Journal of Infectious Diseases

Publication Date





1172 - 1179