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Meningitis remains an important cause of morbidity and mortality among children >5 years of age and is especially prevalent in developing countries. Effective routine immunization against Hib, pneumococcus and serogroupC meningococcus has had a significant impact on both invasive disease and carriage caused by these encapsulated bacteria. The major challenge in prevention of meningitis remains the delivery of vaccines worldwide, especially to resource-poor regions with the greatest disease burden.

Original publication




Journal article


Br Med Bull

Publication Date





65 - 81


Bacterial Proteins, Bacterial Vaccines, Haemophilus Vaccines, Humans, Meningitis, Bacterial, Meningitis, Haemophilus, Meningitis, Meningococcal, Meningococcal Vaccines, Pneumococcal Infections, Pneumococcal Vaccines, Streptococcus agalactiae, Tuberculosis, Tuberculosis Vaccines