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Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Original publication

DOI

10.15252/embj.2021108863

Type

Journal article

Journal

EMBO J

Publication Date

30/08/2021

Keywords

aging, cancer, inflammation, metabolic syndromes, neurodegeneration