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The resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In both L3T4+ and Lyt-2+ T-cell-depleted mice, resistance against subsequent infection with M. tuberculosis was markedly impaired compared with that in untreated controls, with L3T4+ T-cell-depleted mice showing more pronounced effects. Simultaneous depletion of L3T4+ and Lyt-2+ T cells did not further exacerbate infection. These findings suggest that both L3T4+ and Lyt-2+ T cells are involved in the acquisition of resistance against tuberculosis.


Journal article


Infect Immun

Publication Date





2037 - 2041


Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Antigens, Ly, Antigens, Surface, Cytotoxicity, Immunologic, Immunity, Cellular, Male, Mice, Mice, Inbred Strains, Mycobacterium tuberculosis, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Thymectomy, Tuberculosis