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Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins.


Journal article


Pediatr Infect Dis J

Publication Date





452 - 454


CD18 Antigens, Humans, Infant, Newborn, Leukocyte-Adhesion Deficiency Syndrome, Macrophage-1 Antigen, Phagocytosis, Pseudomonas Infections, Pseudomonas aeruginosa