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Expression of CD4 is not sufficient for cellular susceptibility to HIV-1 entry. The majority of nonprimate cells appear to lack a factor that plays an accessory role to CD4 during virus-cell fusion. We have previously reported CD4-dependent entry in rat myeloma Y3 cells, and here we show that Y3 and CD4-expressing mouse L929 cells fuse spontaneously to produce heterokaryons susceptible to entry by HIV-1. The results suggest that a putative accessory factor necessary for entry of HIV-1 into cells is expressed by the nonprimate Y3 cell line.

Original publication




Journal article


AIDS Res Hum Retroviruses

Publication Date





1609 - 1611


Animals, Biological Factors, CD4 Antigens, Cell Fusion, DNA, Viral, Fibroblasts, HIV-1, Humans, Hybrid Cells, Mice, Multiple Myeloma, Rats, Tumor Cells, Cultured