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There are many routes to exploiting tolerance processes to ensure long-term graft survival. Complete tolerance although attractive as a goal, may not be the most practical in the clinic. Instead simple and low-impact procedures that harness tolerance processes used in conjunction with low doses of immunosuppressive drugs may prove the most reliable and user-friendly of approaches.

Original publication




Journal article


Philos Trans R Soc Lond B Biol Sci

Publication Date





659 - 663


Animals, Antibodies, Monoclonal, Antigens, CD, Antigens, Neoplasm, Bone Marrow Transplantation, CD4 Antigens, CD52 Antigen, CD8 Antigens, Glycoproteins, Graft Rejection, Graft vs Host Disease, Humans, Lymphocyte Depletion, Models, Immunological, Transplantation Tolerance