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Vaccines are the most cost-effective resource to contain and eliminate infectious diseases. Despite decades of research in the field, several pathogens have eluded the effect of conventional vaccines mostly due their failure in inducing strong T cell responses. There is a need for new vaccine technologies that can surpass this problem. Recent advances in imaging techniques have allowed the study of T cell dynamics within their surrounding cellular niches. This information is invaluable to elucidate the main cellular mechanisms to target to optimize vaccine efficiency. In this review, we summarize the most recent key discoveries in T cell behavior in the context of immunization.

Original publication

DOI

10.1016/j.biocel.2022.106224

Type

Journal article

Journal

Int J Biochem Cell Biol

Publication Date

07/05/2022

Keywords

T cells, Vaccines, imaging, microenvironments, spatio-temporal dynamics