Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Vaccines are the most cost-effective resource to contain and eliminate infectious diseases. Despite decades of research in the field, several pathogens have eluded the effect of conventional vaccines mostly due their failure in inducing strong T cell responses. There is a need for new vaccine technologies that can surpass this problem. Recent advances in imaging techniques have allowed the study of T cell dynamics within their surrounding cellular niches. This information is invaluable to elucidate the main cellular mechanisms to target to optimize vaccine efficiency. In this review, we summarize the most recent key discoveries in T cell behavior in the context of immunization.

Original publication




Journal article


Int J Biochem Cell Biol

Publication Date



T cells, Vaccines, imaging, microenvironments, spatio-temporal dynamics