Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extracellular volume (ECV) was calculated to be about 23% of total body volume (TV). Stereo metric solution suggested the cubic cell cluster formed by 8-cells. This hypothesis (Solution l) explains the ECV to be compatible with the widely accepted value (about 23% of TV). In addition, the 8-cell cluster hypothesis explains the existence of ECV oscillation with the period of about seven days. This hypothesis probably describes the dominant type of growth in humans. Solution 2, in this type of growth, ECV fills about 77% per cent of TV. Instead of the 8-cell cube, in this type of proliferation 4-cells could form a tetrahedron. This type of growth could be beneficial in processes where free space in tissue or organ must be filled for example in peptic ulcer healing and namely in repopulating of free space in a bone after high dose chemotherapy. © 2004 Elsevier Ltd. All rights reserved.

Original publication




Journal article


Medical Hypotheses

Publication Date





303 - 306