Interleukin-23 and TH17 cells in transplantation immunity: does 23+17 equal rejection?
Chen Y., Wood KJ.
Interleukin-23 (IL-23) and the recently discovered Th17 cells have been implicated in the pathogenesis of autoimmune diseases. This review will discuss current understanding of T-cell subsets in transplantation immunity and will explore the role of IL-23 and Th17 cells in allograft rejection, tolerance, and ischemia reperfusion injury.