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HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those generated by seropositive individuals who progress to disease at a faster rate. The class I molecule HLA-B*57 has been identified as one restriction element overrepresented in SP groups studied, and, together with the closely related molecule HLA-B*58, occurs commonly in ethnic groups where HIV is most prevalent. In this study, we have identified five new HLA-B*57-restricted CTL epitopes recognized by SP donors, one of which is also HLA-B*5801 restricted. These HLA-B*57-restricted responses represent the dominant HIV-specific CTL response in each of the SP donors tested. These and other such epitopes may be an important component in future vaccine design.

Original publication




Journal article


AIDS Res Hum Retroviruses

Publication Date





1691 - 1698


Amino Acid Sequence, Blood Donors, Disease Progression, Epitopes, T-Lymphocyte, Ethnic Groups, HIV Antigens, HIV Infections, HIV-1, HLA-B Antigens, Humans, Immunodominant Epitopes, Molecular Sequence Data, T-Lymphocytes, Cytotoxic