Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those generated by seropositive individuals who progress to disease at a faster rate. The class I molecule HLA-B*57 has been identified as one restriction element overrepresented in SP groups studied, and, together with the closely related molecule HLA-B*58, occurs commonly in ethnic groups where HIV is most prevalent. In this study, we have identified five new HLA-B*57-restricted CTL epitopes recognized by SP donors, one of which is also HLA-B*5801 restricted. These HLA-B*57-restricted responses represent the dominant HIV-specific CTL response in each of the SP donors tested. These and other such epitopes may be an important component in future vaccine design.

Original publication

DOI

10.1089/aid.1996.12.1691

Type

Journal article

Journal

AIDS Res Hum Retroviruses

Publication Date

10/12/1996

Volume

12

Pages

1691 - 1698

Keywords

Amino Acid Sequence, Blood Donors, Disease Progression, Epitopes, T-Lymphocyte, Ethnic Groups, HIV Antigens, HIV Infections, HIV-1, HLA-B Antigens, Humans, Immunodominant Epitopes, Molecular Sequence Data, T-Lymphocytes, Cytotoxic