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Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols.

Original publication




Conference paper

Publication Date





451 - 472


Adaptation, Physiological, Animals, Cell Division, Cell Hypoxia, Computer Simulation, Humans, Models, Biological, Neoplasm Staging, Neoplasms, Neovascularization, Pathologic, Oxygen, Viscera